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Organophosphine-free copper-catalyzed isothiocyanation of amines with sodium bromodifluoroacetate and sulfur

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Abstract

A copper-catalyzed isothiocyanation of amines with sodium bromodifluoroacetate and sulfur in the absence of organophosphine has been established. This approach represents a simple and efficient one-pot synthesis of isothiocyanates, and features excellent functional group tolerance and the use of a cheap, safe and odorless sulfur source. Moreover, this process could directly provide isothiocyanate analogous bioactive molecules, thiocarbonyl-containing pesticides and facile construction of benzoxazole and benzimidazole frames.

Graphical abstract: Organophosphine-free copper-catalyzed isothiocyanation of amines with sodium bromodifluoroacetate and sulfur

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Publication details

The article was received on 19 Nov 2018, accepted on 02 Jan 2019 and first published on 03 Jan 2019


Article type: Communication
DOI: 10.1039/C8CC09190K
Citation: Chem. Commun., 2019, Advance Article
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    Organophosphine-free copper-catalyzed isothiocyanation of amines with sodium bromodifluoroacetate and sulfur

    W. Feng and X. Zhang, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C8CC09190K

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