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Mitochondria targeted and NADH triggered photodynamic activity of chloromethyl modified Ru(II) complexes under hypoxic conditions

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Abstract

Three chloromethyl-modified Ru(II) complexes were designed and synthesized as mitochondria targeting photosensitizers, which can generate carbon radicals in the presence of NADH under visible light irradiation, cause DNA cleavage and covalent binding in Ar-saturated solutions, and lead to apoptosis of human ovarian carcinoma SKOV-3 cells under hypoxic conditions (3% O2), demonstrating a new mode of type I mechanism to overcome the limitation of hypoxia in photodynamic therapy (PDT).

Graphical abstract: Mitochondria targeted and NADH triggered photodynamic activity of chloromethyl modified Ru(ii) complexes under hypoxic conditions

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Publication details

The article was received on 19 Nov 2018, accepted on 01 Feb 2019 and first published on 12 Feb 2019


Article type: Communication
DOI: 10.1039/C8CC09186B
Citation: Chem. Commun., 2019, Advance Article

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    Mitochondria targeted and NADH triggered photodynamic activity of chloromethyl modified Ru(II) complexes under hypoxic conditions

    N. Tian, W. Sun, X. Guo, J. Lu, C. Li, Y. Hou, X. Wang and Q. Zhou, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C8CC09186B

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