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Issue 14, 2019
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Pd-Catalyzed para-selective C–H difluoromethylation of aromatic carbonyls

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Abstract

A novel palladium catalyzed highly para-selective C–H difluoromethylation of electron-deficient aromatic carbonyls was developed. Diverse substituted aromatic ketones and benzoates were selectively difluoromethylated at the remote para-site of carbonyl groups in moderate to good yields. Moreover, the difuoromethylation was also compatible with several complex bioactive molecules.

Graphical abstract: Pd-Catalyzed para-selective C–H difluoromethylation of aromatic carbonyls

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Publication details

The article was received on 16 Nov 2018, accepted on 10 Dec 2018 and first published on 11 Dec 2018


Article type: Communication
DOI: 10.1039/C8CC09129C
Citation: Chem. Commun., 2019,55, 2019-2022

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    Pd-Catalyzed para-selective C–H difluoromethylation of aromatic carbonyls

    Y. Mao, B. Wang, Q. Wu, K. Zhou, S. Lou and D. Xu, Chem. Commun., 2019, 55, 2019
    DOI: 10.1039/C8CC09129C

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