Jump to main content
Jump to site search


Pd-Catalyzed para-selective C–H difluoromethylation of aromatic carbonyls

Author affiliations

Abstract

A novel palladium catalyzed highly para-selective C–H difluoromethylation of electron-deficient aromatic carbonyls was developed. Diverse substituted aromatic ketones and benzoates were selectively difluoromethylated at the remote para-site of carbonyl groups in moderate to good yields. Moreover, the difuoromethylation was also compatible with several complex bioactive molecules.

Graphical abstract: Pd-Catalyzed para-selective C–H difluoromethylation of aromatic carbonyls

Back to tab navigation

Supplementary files

Publication details

The article was received on 16 Nov 2018, accepted on 10 Dec 2018 and first published on 11 Dec 2018


Article type: Communication
DOI: 10.1039/C8CC09129C
Citation: Chem. Commun., 2019, Advance Article
  •   Request permissions

    Pd-Catalyzed para-selective C–H difluoromethylation of aromatic carbonyls

    Y. Mao, B. Wang, Q. Wu, K. Zhou, S. Lou and D. Xu, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C8CC09129C

Search articles by author

Spotlight

Advertisements