Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 27th March 2019 from 11:00 AM to 1:00 PM (GMT).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 10, 2019
Previous Article Next Article

Anti-glioma trichobamide A with an unprecedented tetrahydro-5H-furo[2,3-b]pyrrol-5-one functionality from ascidian-derived fungus Trichobotrys effuse 4729

Author affiliations

Abstract

Trichobamide A (1), a novel pyrrocidine alkaloid with an unprecedented tetrahydro-5H-furo[2,3-b]pyrrol-5-one moiety, was isolated from the ascidian-derived fungus Trichobotrys effuse 4729. Trichobamide A (1) showed significant inhibition of the proliferation of two glioma cell lines, U251 and SNB19. It induced the up-regulation of P53 expression, which in turn induces the up-regulation of downstream pro-apoptotic gene expression and the down-regulation of anti-apoptotic gene expression.

Graphical abstract: Anti-glioma trichobamide A with an unprecedented tetrahydro-5H-furo[2,3-b]pyrrol-5-one functionality from ascidian-derived fungus Trichobotrys effuse 4729

Back to tab navigation

Supplementary files

Publication details

The article was received on 11 Nov 2018, accepted on 08 Jan 2019 and first published on 08 Jan 2019


Article type: Communication
DOI: 10.1039/C8CC08970A
Citation: Chem. Commun., 2019,55, 1438-1441

  •   Request permissions

    Anti-glioma trichobamide A with an unprecedented tetrahydro-5H-furo[2,3-b]pyrrol-5-one functionality from ascidian-derived fungus Trichobotrys effuse 4729

    S. Chen, H. Shen, P. Zhang, H. Cheng, X. Dai and L. Liu, Chem. Commun., 2019, 55, 1438
    DOI: 10.1039/C8CC08970A

Search articles by author

Spotlight

Advertisements