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Issue 4, 2019
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Fe3O4–ZIF-8 assemblies as pH and glutathione responsive T2T1 switching magnetic resonance imaging contrast agent for sensitive tumor imaging in vivo

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Abstract

A small Fe3O4 nanoparticles-based T1 contrast agent was assembled into a pH- and glutathione-responsive T2T1 switching contrast agent, Fe3O4–ZIF-8. In vivo T1-weighted images of mice showed that Fe3O4–ZIF-8 displayed darkening contrast enhancement for liver sites, while darkening to brightening contrast enhancement at tumor sites, giving large inverse contrast for distinguishing the normal and tumor tissues.

Graphical abstract: Fe3O4–ZIF-8 assemblies as pH and glutathione responsive T2–T1 switching magnetic resonance imaging contrast agent for sensitive tumor imaging in vivo

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Publication details

The article was received on 10 Nov 2018, accepted on 28 Nov 2018 and first published on 29 Nov 2018


Article type: Communication
DOI: 10.1039/C8CC08943D
Citation: Chem. Commun., 2019,55, 478-481

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    Fe3O4–ZIF-8 assemblies as pH and glutathione responsive T2T1 switching magnetic resonance imaging contrast agent for sensitive tumor imaging in vivo

    J. Lin, P. Xin, L. An, Y. Xu, C. Tao, Q. Tian, Z. Zhou, B. Hu and S. Yang, Chem. Commun., 2019, 55, 478
    DOI: 10.1039/C8CC08943D

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