Jump to main content
Jump to site search

Issue 6, 2019
Previous Article Next Article

A multifunctional toolkit for target-directed cancer therapy

Author affiliations

Abstract

Here we present 2shRNA, a shRNA-based nanobinder, which can simultaneously attack two therapeutic targets involved in drug resistance pathways and can additionally bind accessory molecules such as cell targeting peptides or fluorophores. We create 2shRNAs designed to specifically kill HER2+ breast cancer cells in the absence of a transfecting agent.

Graphical abstract: A multifunctional toolkit for target-directed cancer therapy

Back to tab navigation

Supplementary files

Article information


Submitted
05 Nov 2018
Accepted
14 Dec 2018
First published
14 Dec 2018

Chem. Commun., 2019,55, 802-805
Article type
Communication

A multifunctional toolkit for target-directed cancer therapy

M. Terrazas, D. Sánchez, F. Battistini, N. Villegas, I. Brun-Heath and M. Orozco, Chem. Commun., 2019, 55, 802
DOI: 10.1039/C8CC08823C

Social activity

Search articles by author

Spotlight

Advertisements