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Issue 6, 2019
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A multifunctional toolkit for target-directed cancer therapy

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Abstract

Here we present 2shRNA, a shRNA-based nanobinder, which can simultaneously attack two therapeutic targets involved in drug resistance pathways and can additionally bind accessory molecules such as cell targeting peptides or fluorophores. We create 2shRNAs designed to specifically kill HER2+ breast cancer cells in the absence of a transfecting agent.

Graphical abstract: A multifunctional toolkit for target-directed cancer therapy

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Publication details

The article was received on 05 Nov 2018, accepted on 14 Dec 2018 and first published on 14 Dec 2018


Article type: Communication
DOI: 10.1039/C8CC08823C
Chem. Commun., 2019,55, 802-805

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    A multifunctional toolkit for target-directed cancer therapy

    M. Terrazas, D. Sánchez, F. Battistini, N. Villegas, I. Brun-Heath and M. Orozco, Chem. Commun., 2019, 55, 802
    DOI: 10.1039/C8CC08823C

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