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Customized mesoporous metal organic frameworks engender stable enzymatic nanoreactors

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Abstract

Here, the porosity of a metal organic framework (MIL-101) is tailored by the choice of the solvent occupying the pores in a template free acid etching process. Employing a slightly basic solvent such as DMF afforded big pores around 30 nm (BP-MIL-101). Catalase (CAT), which is a large protein (6 × 10 nm), was successfully encapsulated by a diffusion-based method with a high capacity of 12.5%. BP-MIL-101 could successfully protect CAT from both digestion and denaturation while maintaining its catalytic activity. This paves the way for encapsulating different large biological targets for eventual translation and delivery.

Graphical abstract: Customized mesoporous metal organic frameworks engender stable enzymatic nanoreactors

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Publication details

The article was received on 04 Nov 2018, accepted on 01 Dec 2018 and first published on 06 Dec 2018


Article type: Communication
DOI: 10.1039/C8CC08790C
Citation: Chem. Commun., 2019, Advance Article
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    Customized mesoporous metal organic frameworks engender stable enzymatic nanoreactors

    L. Zhang, W. Baslyman, P. Yang and N. M. Khashab, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C8CC08790C

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