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Issue 10, 2019
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Trastuzumab gold-conjugates: synthetic approach and in vitro evaluation of anticancer activities in breast cancer cell lines

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Abstract

We describe the preparation of gold(I)-compounds that are amenable to efficient bioconjugation with monoclonal antibodies via activated ester or maleimide linkers. New Trastuzumab–gold conjugates were synthesized and fully characterized. These bioconjugates are significantly more cytotoxic (sub-micromolar range) to HER2-positive breast cancer cells than the gold complexes and Trastuzumab.

Graphical abstract: Trastuzumab gold-conjugates: synthetic approach and in vitro evaluation of anticancer activities in breast cancer cell lines

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Article information


Submitted
03 Nov 2018
Accepted
04 Jan 2019
First published
04 Jan 2019

Chem. Commun., 2019,55, 1394-1397
Article type
Communication

Trastuzumab gold-conjugates: synthetic approach and in vitro evaluation of anticancer activities in breast cancer cell lines

N. Curado, G. Dewaele-Le Roi, S. Poty, J. S. Lewis and M. Contel, Chem. Commun., 2019, 55, 1394
DOI: 10.1039/C8CC08769E

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