Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 27th March 2019 from 11:00 AM to 1:00 PM (GMT).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 7, 2019
Previous Article Next Article

Electrochemical benzylic oxidation of C–H bonds

Author affiliations

Abstract

Oxidized products have become increasingly valuable as building blocks for a wide variety of different processes and fine chemistry, especially in the benzylic position. We report herein a sustainable protocol for this transformation through C–H functionalization and is performed using electrochemistry as the main power source and tert-butyl hydroperoxide as the radical source for the C–H abstraction. The temperature conditions reported here do not increase above 50 °C and use an aqueous-based medium. A broad substrate scope is explored, along with bioactive molecules, to give comparable and increased product yields when compared to prior reported literature without the use of electrochemistry.

Graphical abstract: Electrochemical benzylic oxidation of C–H bonds

Back to tab navigation

Supplementary files

Publication details

The article was received on 02 Nov 2018, accepted on 19 Dec 2018 and first published on 02 Jan 2019


Article type: Communication
DOI: 10.1039/C8CC08768G
Citation: Chem. Commun., 2019,55, 937-940

  •   Request permissions

    Electrochemical benzylic oxidation of C–H bonds

    J. A. Marko, A. Durgham, S. L. Bretz and W. Liu, Chem. Commun., 2019, 55, 937
    DOI: 10.1039/C8CC08768G

Search articles by author

Spotlight

Advertisements