Jump to main content
Jump to site search

Issue 7, 2019
Previous Article Next Article

Electrochemical benzylic oxidation of C–H bonds

Author affiliations

Abstract

Oxidized products have become increasingly valuable as building blocks for a wide variety of different processes and fine chemistry, especially in the benzylic position. We report herein a sustainable protocol for this transformation through C–H functionalization and is performed using electrochemistry as the main power source and tert-butyl hydroperoxide as the radical source for the C–H abstraction. The temperature conditions reported here do not increase above 50 °C and use an aqueous-based medium. A broad substrate scope is explored, along with bioactive molecules, to give comparable and increased product yields when compared to prior reported literature without the use of electrochemistry.

Graphical abstract: Electrochemical benzylic oxidation of C–H bonds

Back to tab navigation

Supplementary files

Article information


Submitted
02 Nov 2018
Accepted
19 Dec 2018
First published
02 Jan 2019

Chem. Commun., 2019,55, 937-940
Article type
Communication
Author version available

Electrochemical benzylic oxidation of C–H bonds

J. A. Marko, A. Durgham, S. L. Bretz and W. Liu, Chem. Commun., 2019, 55, 937
DOI: 10.1039/C8CC08768G

Social activity

Search articles by author

Spotlight

Advertisements