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Electrochemical benzylic oxidation of C–H bonds

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Abstract

Oxidized products have become increasingly valuable as building blocks for a wide variety of different processes and fine chemistry, especially in the benzylic position. We report herein a sustainable protocol for this transformation through C–H functionalization and is performed using electrochemistry as the main power source and tert-butyl hydroperoxide as the radical source for the C–H abstraction. The temperature conditions reported here do not increase above 50 °C and use an aqueous-based medium. A broad substrate scope is explored, along with bioactive molecules, to give comparable and increased product yields when compared to prior reported literature without the use of electrochemistry.

Graphical abstract: Electrochemical benzylic oxidation of C–H bonds

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Publication details

The article was received on 02 Nov 2018, accepted on 19 Dec 2018 and first published on 02 Jan 2019


Article type: Communication
DOI: 10.1039/C8CC08768G
Citation: Chem. Commun., 2019, Advance Article
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    Electrochemical benzylic oxidation of C–H bonds

    J. A. Marko, A. Durgham, S. L. Bretz and W. Liu, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C8CC08768G

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