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Sulfo-click chemistry with 18F-labeled thio acids

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Abstract

The first application of sulfo-click chemistry with 18F-labeled thio acids is described. The simple one-pot/three-component reaction proceeded rapidly within 30 min using mild reaction conditions to give various 18F-labeled small molecule N-acylsulfonamides in radiochemical conversions of 38–99%, and radiolabeled peptides in 20–25% isolated and decay-corrected radiochemical yields.

Graphical abstract: Sulfo-click chemistry with 18F-labeled thio acids

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Publication details

The article was received on 31 Oct 2018, accepted on 08 Jan 2019 and first published on 08 Jan 2019


Article type: Communication
DOI: 10.1039/C8CC08717B
Citation: Chem. Commun., 2019, Advance Article
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    Sulfo-click chemistry with 18F-labeled thio acids

    J. Urkow, C. Bergman and F. Wuest, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C8CC08717B

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