Jump to main content
Jump to site search


Solid-phase synthesis for thalidomide-based proteolysis-targeting chimeras (PROTAC)

Author affiliations

Abstract

A preloaded resin consisting of a thalidomide moiety and an ethylene-oxy linker allows the simple and fast formation of PROTACs. The feasibility of the procedure was illustrated by conjugating different protein kinase inhibitors. The biological functionality of an ibrutinib-like conjugate was then confirmed by a cellular experiment.

Graphical abstract: Solid-phase synthesis for thalidomide-based proteolysis-targeting chimeras (PROTAC)

Back to tab navigation

Supplementary files

Publication details

The article was received on 01 Nov 2018, accepted on 17 Dec 2018 and first published on 17 Dec 2018


Article type: Communication
DOI: 10.1039/C8CC08716D
Citation: Chem. Commun., 2019, Advance Article
  •   Request permissions

    Solid-phase synthesis for thalidomide-based proteolysis-targeting chimeras (PROTAC)

    S. Krajcovicova, R. Jorda, D. Hendrychova, V. Krystof and M. Soural, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C8CC08716D

Search articles by author

Spotlight

Advertisements