Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 22nd May 2019 from 11:00 AM to 1:00 PM (GMT).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 7, 2019
Previous Article Next Article

Solid-phase synthesis for thalidomide-based proteolysis-targeting chimeras (PROTAC)

Author affiliations

Abstract

A preloaded resin consisting of a thalidomide moiety and an ethylene-oxy linker allows the simple and fast formation of PROTACs. The feasibility of the procedure was illustrated by conjugating different protein kinase inhibitors. The biological functionality of an ibrutinib-like conjugate was then confirmed by a cellular experiment.

Graphical abstract: Solid-phase synthesis for thalidomide-based proteolysis-targeting chimeras (PROTAC)

Back to tab navigation

Supplementary files

Publication details

The article was received on 01 Nov 2018, accepted on 17 Dec 2018 and first published on 17 Dec 2018


Article type: Communication
DOI: 10.1039/C8CC08716D
Chem. Commun., 2019,55, 929-932

  •   Request permissions

    Solid-phase synthesis for thalidomide-based proteolysis-targeting chimeras (PROTAC)

    S. Krajcovicova, R. Jorda, D. Hendrychova, V. Krystof and M. Soural, Chem. Commun., 2019, 55, 929
    DOI: 10.1039/C8CC08716D

Search articles by author

Spotlight

Advertisements