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Coupling effects of thiol and urea-type groups for promotion of oxidative protein folding

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Abstract

Coupling of thiol and urea-type –NHC([double bond, length as m-dash]X)NH2 (X = O or NH) groups is effective in promoting oxidative protein folding. In particular, a thiol compound coupled with a guanidyl (X = NH) group significantly accelerates the rates of folding processes and enhances the yields of native proteins.

Graphical abstract: Coupling effects of thiol and urea-type groups for promotion of oxidative protein folding

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Publication details

The article was received on 30 Oct 2018, accepted on 26 Nov 2018 and first published on 27 Nov 2018


Article type: Communication
DOI: 10.1039/C8CC08657E
Citation: Chem. Commun., 2019, Advance Article
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    Coupling effects of thiol and urea-type groups for promotion of oxidative protein folding

    S. Okada, M. Matsusaki, K. Arai, Y. Hidaka, K. Inaba, M. Okumura and T. Muraoka, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C8CC08657E

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