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Issue 6, 2019
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Coupling effects of thiol and urea-type groups for promotion of oxidative protein folding

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Abstract

Coupling of thiol and urea-type –NHC([double bond, length as m-dash]X)NH2 (X = O or NH) groups is effective in promoting oxidative protein folding. In particular, a thiol compound coupled with a guanidyl (X = NH) group significantly accelerates the rates of folding processes and enhances the yields of native proteins.

Graphical abstract: Coupling effects of thiol and urea-type groups for promotion of oxidative protein folding

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Supplementary files

Article information


Submitted
30 Oct 2018
Accepted
26 Nov 2018
First published
27 Nov 2018

Chem. Commun., 2019,55, 759-762
Article type
Communication

Coupling effects of thiol and urea-type groups for promotion of oxidative protein folding

S. Okada, M. Matsusaki, K. Arai, Y. Hidaka, K. Inaba, M. Okumura and T. Muraoka, Chem. Commun., 2019, 55, 759
DOI: 10.1039/C8CC08657E

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