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Regioselective 5′-position phosphorylation of ribose and ribonucleosides: phosphate transfer in the activated pyrophosphate complex in the gas phase

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Abstract

Herein, we present a rapid, efficient and regioselective phosphorylation method at the 5′-position of unprotected ribose and ribonucleosides with pyrophosphate in the gas phase, which involves the formation of anionic complexes via electrospray ionization and collisional activation to induce phosphorylation within the complexes.

Graphical abstract: Regioselective 5′-position phosphorylation of ribose and ribonucleosides: phosphate transfer in the activated pyrophosphate complex in the gas phase

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Publication details

The article was received on 24 Oct 2018, accepted on 15 Nov 2018 and first published on 15 Nov 2018


Article type: Communication
DOI: 10.1039/C8CC08510B
Citation: Chem. Commun., 2019, Advance Article
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    Regioselective 5′-position phosphorylation of ribose and ribonucleosides: phosphate transfer in the activated pyrophosphate complex in the gas phase

    J. Hu, W. Lei, J. Wang, H. Chen and J. Xu, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C8CC08510B

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