Jump to main content
Jump to site search

Issue 18, 2019
Previous Article Next Article

DNA aptamer assemblies as fibroblast growth factor mimics and their application in stem cell culture

Author affiliations

Abstract

Replacing expensive and thermally unstable growth factors with synthetic alternatives has been an important issue in stem cell-based regenerative medicines. Here we developed DNA aptamer-assemblies that act as functional mimics of basic fibroblast growth factor (bFGF), one of the essential factors for stem cell culture. The most potent aptamer assembly named TD0, composed solely of 76-mer single-stranded DNA, could support the self-renewal and pluripotency of induced pluripotent stem cells (iPSCs). This work presents the first application of DNA aptamer in the maintenance of iPSCs.

Graphical abstract: DNA aptamer assemblies as fibroblast growth factor mimics and their application in stem cell culture

Back to tab navigation

Supplementary files

Article information


Submitted
09 Oct 2018
Accepted
04 Feb 2019
First published
05 Feb 2019

Chem. Commun., 2019,55, 2672-2675
Article type
Communication
Author version available

DNA aptamer assemblies as fibroblast growth factor mimics and their application in stem cell culture

R. Ueki, S. Atsuta, A. Ueki, J. Hoshiyama, J. Li, Y. Hayashi and S. Sando, Chem. Commun., 2019, 55, 2672
DOI: 10.1039/C8CC08080A

Social activity

Search articles by author

Spotlight

Advertisements