Jump to main content
Jump to site search


DNA aptamer assemblies as fibroblast growth factor mimics and their application in stem cell culture

Author affiliations

Abstract

Replacing expensive and thermally unstable growth factors with synthetic alternatives has been an important issue in stem cell-based regenerative medicines. Here we developed DNA aptamer-assemblies that act as functional mimics of basic fibroblast growth factor (bFGF), one of the essential factors for stem cell culture. The most potent aptamer assembly named TD0, composed solely of 76-mer single-stranded DNA, could support the self-renewal and pluripotency of induced pluripotent stem cells (iPSCs). This work presents the first application of DNA aptamer in the maintenance of iPSCs.

Graphical abstract: DNA aptamer assemblies as fibroblast growth factor mimics and their application in stem cell culture

Back to tab navigation

Supplementary files

Publication details

The article was received on 09 Oct 2018, accepted on 04 Feb 2019 and first published on 05 Feb 2019


Article type: Communication
DOI: 10.1039/C8CC08080A
Citation: Chem. Commun., 2019, Advance Article

  •   Request permissions

    DNA aptamer assemblies as fibroblast growth factor mimics and their application in stem cell culture

    R. Ueki, S. Atsuta, A. Ueki, J. Hoshiyama, J. Li, Y. Hayashi and S. Sando, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C8CC08080A

Search articles by author

Spotlight

Advertisements