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Issue 1, 2019
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Biocatalytically induced surface modification of the tobacco mosaic virus and the bacteriophage M13

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Abstract

Engineered viruses are finding an increasing number of applications in basic, translational research and materials science. Genetic and chemical engineering of capsids represents a key point for tailoring the properties of viral particles, but the synthetic efforts and limits accompanying these processes still hinder their usability. Here, a single-step highly selective biocatalytic functionalization approach is described, providing a general platform for virus–acrylate hybrid particles. The tobacco mosaic virus (TMV) and the bacteriophage M13 have been successfully modified via laccase induced free radical formation on the tyrosine residues through single electron oxidation as the initiating step and the free radicals subsequently react with acrylate-based monomers. This new approach can be extended to other biomolecular assemblies with surface exposed tyrosine residues, when the introduction of new functionalities is desired.

Graphical abstract: Biocatalytically induced surface modification of the tobacco mosaic virus and the bacteriophage M13

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Supplementary files

Article information


Submitted
08 Oct 2018
Accepted
28 Nov 2018
First published
28 Nov 2018

Chem. Commun., 2019,55, 51-54
Article type
Communication

Biocatalytically induced surface modification of the tobacco mosaic virus and the bacteriophage M13

V. Vignali, B. S. Miranda, I. Lodoso-Torrecilla, C. A. J. van Nisselroy, B. Hoogenberg, S. Dantuma, F. Hollmann, J. W. de Vries, E. M. Warszawik, R. Fischer, U. Commandeur and P. van Rijn, Chem. Commun., 2019, 55, 51
DOI: 10.1039/C8CC08042A

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