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Issue 7, 2019
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Biocatalytic selective functionalisation of alkenes via single-step and one-pot multi-step reactions

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Abstract

Alkenes are excellent starting materials for organic synthesis due to the versatile reactivity of C[double bond, length as m-dash]C bonds and the easy availability of many unfunctionalised alkenes. Direct regio- and/or enantioselective conversion of alkenes into functionalised (chiral) compounds has enormous potential for industrial applications, and thus has attracted the attention of researchers for extensive development using chemo-catalysis over the past few years. On the other hand, many enzymes have also been employed for conversion of alkenes in a highly selective and much greener manner to offer valuable products. Herein, we review recent advances in seven well-known types of biocatalytic conversion of alkenes. Remarkably, recent mechanism-guided directed evolution and enzyme cascades have enabled the development of seven novel types of single-step and one-pot multi-step functionalisation of alkenes, some of which are even unattainable via chemo-catalysis. These new reactions are particularly highlighted in this feature article. Overall, we present an ever-expanding enzyme toolbox for various alkene functionalisations inspiring further research in this fast-developing theme.

Graphical abstract: Biocatalytic selective functionalisation of alkenes via single-step and one-pot multi-step reactions

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Publication details

The article was received on 30 Sep 2018, accepted on 10 Dec 2018 and first published on 11 Dec 2018


Article type: Feature Article
DOI: 10.1039/C8CC07828A
Citation: Chem. Commun., 2019,55, 883-896

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    Biocatalytic selective functionalisation of alkenes via single-step and one-pot multi-step reactions

    S. Wu, Y. Zhou and Z. Li, Chem. Commun., 2019, 55, 883
    DOI: 10.1039/C8CC07828A

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