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β-Glucan as an immune activator and a carrier in the construction of a synthetic MUC1 vaccine

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Abstract

We describe the preparation of a cancer vaccine candidate by conjugating a MUC1 peptide antigen to the β-glucan polysaccharide, which serves both as a carrier and an immune activator. In contrast to amorphous polysaccharides, peptide–β-glucan conjugates form uniform nanoparticles that facilitate the delivery of antigens and binding to myeloid cells, thus leading to the activation of both innate and adaptive immunity.

Graphical abstract: β-Glucan as an immune activator and a carrier in the construction of a synthetic MUC1 vaccine

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Publication details

The article was received on 25 Sep 2018, accepted on 03 Dec 2018 and first published on 03 Dec 2018


Article type: Communication
DOI: 10.1039/C8CC07691J
Citation: Chem. Commun., 2019, Advance Article
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    β-Glucan as an immune activator and a carrier in the construction of a synthetic MUC1 vaccine

    H. Wang, B. Yang, Y. Wang, F. Liu, A. Fernández-Tejada and S. Dong, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C8CC07691J

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