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A mitochondria-targeted nitric oxide donor triggered by superoxide radical to alleviate myocardial ischemia/reperfusion injury

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Abstract

A novel mitochondria-targeted superoxide-responsive nitric oxide donor was developed by incorporation of diphenylphosphinyl and triphenylphosphonium groups into diazeniumdiolate, enabling remarkable protection against ischemia/reperfusion injury in H9c2 cells and isolated rat hearts.

Graphical abstract: A mitochondria-targeted nitric oxide donor triggered by superoxide radical to alleviate myocardial ischemia/reperfusion injury

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Publication details

The article was received on 08 Sep 2018, accepted on 20 Nov 2018 and first published on 20 Nov 2018


Article type: Communication
DOI: 10.1039/C8CC07304J
Citation: Chem. Commun., 2019, Advance Article
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    A mitochondria-targeted nitric oxide donor triggered by superoxide radical to alleviate myocardial ischemia/reperfusion injury

    J. Hou, H. He, S. Huang, M. Qian, J. Wang, X. Tan, G. Han, Y. Song, Z. Xu and Y. Liu, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C8CC07304J

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