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Robust alginate/hyaluronic acid thiol-yne click-hydrogel scaffolds with superior mechanical performance and stability for load-bearing soft tissue engineering

Abstract

Hydrogels based on hyaluronic acid (HA) exhibit great potential as tissue engineering (TE) scaffolds for cartilage regeneration as a consequence of their unique biological features. Herein, we examine how the advantages of two natural polymers (i.e. HA and alginate) are combined with the efficiency and rapid nature of the thiol-yne click chemistry reaction to obtain biocompatible matrices with tailored properties. Our injectable click-hydrogels revealed excellent mechanical performance, long-term stability, high cytocompatibility and adequate stiffness for the targeted application. This simple approach yielded HA hydrogels with characteristics that make them suitable for applications as 3D scaffolds to support and promote chondrogenesis.

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Publication details

The article was received on 16 Sep 2019, accepted on 31 Oct 2019 and first published on 06 Nov 2019


Article type: Paper
DOI: 10.1039/C9BM01494B
Biomater. Sci., 2019, Accepted Manuscript
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    Robust alginate/hyaluronic acid thiol-yne click-hydrogel scaffolds with superior mechanical performance and stability for load-bearing soft tissue engineering

    M. Perez-Madrigal, J. Shaw, M. C. Arno, J. Hoyland, S. M. Richardson and A. P. Dove, Biomater. Sci., 2019, Accepted Manuscript , DOI: 10.1039/C9BM01494B

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