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Clickable, acid labile immunosuppressive prodrugs for in vivo targeting

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Abstract

Allotransplantation offers the potential to restore the anatomy and function of injured tissues and organs, but typically requires life-long, systemic administration of immunosuppressive drugs to prevent rejection, which can result in serious complications. Targeting the immunosuppressive drug to the graft favors local tissue concentration versus systemic drug exposure and end-organ toxicity. This could reduce the overall dose and dosing frequency of immunosuppressive drugs, and improve the safety and efficacy of treatment. Here, we developed dibenzocyclooctyne (DBCO)-modified prodrugs of the immunosuppressive drugs tacrolimus, rapamycin and mycophenolic acid, and demonstrated their targeted conjugation both in vitro and in vivo to azido-modified hydrogels via Click chemistry. Such azido-modified hydrogels placed in transplanted tissues enable sustained local release of drugs, and could be repeatedly refilled with systemically administered acid-labile prodrugs after drug exhaustion. Thus, clickable prodrugs with degradable linkers provide new possibilities for graft targeted immunosuppression in the context of allotransplantation.

Graphical abstract: Clickable, acid labile immunosuppressive prodrugs for in vivo targeting

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Publication details

The article was received on 15 Sep 2019, accepted on 30 Oct 2019 and first published on 30 Oct 2019


Article type: Paper
DOI: 10.1039/C9BM01487J
Biomater. Sci., 2020, Advance Article

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    Clickable, acid labile immunosuppressive prodrugs for in vivo targeting

    H. Wang, M. C. Sobral, T. Snyder, Y. Brudno, V. S. Gorantla and D. J. Mooney, Biomater. Sci., 2020, Advance Article , DOI: 10.1039/C9BM01487J

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