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Biomimetic Cell-derived Nanocarriers for Modulating Immune Responses

Abstract

Immunotherapy has become an increasingly important area in the medical field at present. As it is often difficult for synthetic carriers to meet regulatory hurdles for clinical translation, bionic cell-derived carriers are attracting considerable interests due to their better biocompatibility and lower toxicity. Moreover, biomimetic cell-derived nanocarriers may achieve different specific biological effects due to the benefit from their host attributes. In this review, we introduced the technologies that are under extensively investigation, including extracellular vesicles-based formulation technology and cell membrane coating technology, summarized various applications that have been developed based on these technologies for modulating immune responses, and briefly discussed the future perspectives of this field. With a better understanding of these biomimetic technologies, in conjunction with the current advanced biotechnology methods, we expect the continuing development of biomimetic cell-derived nanocarriers will promote their clinic applications.

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Publication details

The article was received on 08 Sep 2019, accepted on 04 Nov 2019 and first published on 04 Nov 2019


Article type: Review Article
DOI: 10.1039/C9BM01444F
Biomater. Sci., 2019, Accepted Manuscript

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    Biomimetic Cell-derived Nanocarriers for Modulating Immune Responses

    M. Qin, G. Du and X. Sun, Biomater. Sci., 2019, Accepted Manuscript , DOI: 10.1039/C9BM01444F

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