Biomimetic Cell-derived Nanocarriers for Modulating Immune Responses
Immunotherapy has become an increasingly important area in the medical field at present. As it is often difficult for synthetic carriers to meet regulatory hurdles for clinical translation, bionic cell-derived carriers are attracting considerable interests due to their better biocompatibility and lower toxicity. Moreover, biomimetic cell-derived nanocarriers may achieve different specific biological effects due to the benefit from their host attributes. In this review, we introduced the technologies that are under extensively investigation, including extracellular vesicles-based formulation technology and cell membrane coating technology, summarized various applications that have been developed based on these technologies for modulating immune responses, and briefly discussed the future perspectives of this field. With a better understanding of these biomimetic technologies, in conjunction with the current advanced biotechnology methods, we expect the continuing development of biomimetic cell-derived nanocarriers will promote their clinic applications.
- This article is part of the themed collection: Biomimetic Therapeutics