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Biomimetic cell-derived nanocarriers for modulating immune responses

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Abstract

Immunotherapy has become an increasingly important area in the medical field at present. As it is often difficult for synthetic carriers to overcome regulatory hurdles for clinical translation, bionic cell-derived carriers are attracting considerable interest due to their better biocompatibility and lower toxicity. Moreover, biomimetic cell-derived nanocarriers may achieve different specific biological effects due to the benefit from their host attributes. In this review, we introduce the technologies that are under extensive investigation, including extracellular vesicle-based formulation technology and cell membrane coating technology, summarize various applications that have been developed based on these technologies for modulating immune responses, and briefly discuss the future perspectives of this field. With a better understanding of these biomimetic technologies, in conjunction with the current advanced biotechnology methods, we expect that the continuing development of biomimetic cell-derived nanocarriers will promote their clinical applications.

Graphical abstract: Biomimetic cell-derived nanocarriers for modulating immune responses

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Publication details

The article was received on 08 Sep 2019, accepted on 04 Nov 2019 and first published on 04 Nov 2019


Article type: Review Article
DOI: 10.1039/C9BM01444F
Biomater. Sci., 2020, Advance Article

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    Biomimetic cell-derived nanocarriers for modulating immune responses

    M. Qin, G. Du and X. Sun, Biomater. Sci., 2020, Advance Article , DOI: 10.1039/C9BM01444F

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