“Imitative”click chemistry to form a sticking xerogel for portable therapy of bacterial-infected wounds
Xerogels usually possess stable structure and have a low swelling rate due to their inferior dynamics. Herein, a xerogel were synthesized by "imitative" click chemistry based on lipoic acid for picking up bacteria on wound sites and thus accelerating tissue repair. The cross-linking structure of disulfide and thioether inside the xerogel not only exhibited good ductility and intrinsic self-healing performance, but also showed superior biocompatibility and captured bacteria of Staphylococcus aureus almost more than 60% in the colonies number of 106 by strong electrostatic adsorption. In addition, this xerogel can stick to skin in the form of patches in the wounds during therapy for wound healing and can be easily stripped from the skin after treatment, which makes it appropriate for portable therapy of bacterial-infected wounds in emergency circumstances.