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“Imitative”click chemistry to form a sticking xerogel for portable therapy of bacterial-infected wounds 

Abstract

Xerogels usually possess stable structure and have a low swelling rate due to their inferior dynamics. Herein, a xerogel were synthesized by "imitative" click chemistry based on lipoic acid for picking up bacteria on wound sites and thus accelerating tissue repair. The cross-linking structure of disulfide and thioether inside the xerogel not only exhibited good ductility and intrinsic self-healing performance, but also showed superior biocompatibility and captured bacteria of Staphylococcus aureus almost more than 60% in the colonies number of 106 by strong electrostatic adsorption. In addition, this xerogel can stick to skin in the form of patches in the wounds during therapy for wound healing and can be easily stripped from the skin after treatment, which makes it appropriate for portable therapy of bacterial-infected wounds in emergency circumstances.

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Publication details

The article was received on 03 Sep 2019, accepted on 05 Oct 2019 and first published on 07 Oct 2019


Article type: Paper
DOI: 10.1039/C9BM01417A
Biomater. Sci., 2019, Accepted Manuscript

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    “Imitative”click chemistry to form a sticking xerogel for portable therapy of bacterial-infected wounds

    B. Huang, X. Liu, L. Tan, Z. Cui, X. Yang, D. Jing, D. Zheng, Z. Li, Y. Liang, S. Zhu, K. Yeung, X. Wang, Y. Zheng and S. Wu, Biomater. Sci., 2019, Accepted Manuscript , DOI: 10.1039/C9BM01417A

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