Biomimetic drug-delivery system for the management of brain diseases
Acting as a double-edged sword, the blood-brain barrier (BBB) is essential for maintaining brain homeostasis by restricting the entry of small molecules and most macromolecules from the blood. However, it also largely limits the brain delivery of most drugs. Even if a drug can penetrate the BBB, its accumulation to the intracerebral pathological regions is relatively low. Thus, an optimal drug-delivery system (DDS) for the management of brain diseases needs to display BBB permeability, lesion-targeting capability, and acceptable safety. Biomimetic DDS, developed by directly utilizing or mimicking the biological structures and processes, provides promising approaches for overcoming the barriers to brain drug delivery. The present review summarizes the biological properties and biomedical applications of the biomimetic DDS including cell membrane-based DDS, lipoprotein-based DDS, exosome-based DDS, virus-based DDS, protein templates-based DDS and peptide templates-based DDS for the management of brain diseases.
- This article is part of the themed collection: Biomimetic Therapeutics