Recent progresses in supramolecular peptide assembly as virus mimicry for cancer immunotherapy
Immunotherapy revolutionizes the field of cancer therapy. Nanomaterials can further improve the efficacy and safety of immunotherapy because of their tunability and multifunctionality. Supramolecular peptide assembly (SPA), as a close mimicry of natural viruses, is a unique type of nanomaterials with high epitope valency, multifunctionality and biocompatibility. Given its great potential in cancer immunotherapy especially in cancer vaccines, in the current review, we summarize the unique features of SPA that are beneficial for cancer immunotherapy, and highlight important progresses in using SPA as nanoscale carriers, antigens, adjuvants or multifunctional platforms. The current challenges faced by these SPAs are also briefly discussed.
- This article is part of the themed collection: Biomimetic Therapeutics