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Recent progresses in supramolecular peptide assembly as virus mimicry for cancer immunotherapy

Abstract

Immunotherapy revolutionizes the field of cancer therapy. Nanomaterials can further improve the efficacy and safety of immunotherapy because of their tunability and multifunctionality. Supramolecular peptide assembly (SPA), as a close mimicry of natural viruses, is a unique type of nanomaterials with high epitope valency, multifunctionality and biocompatibility. Given its great potential in cancer immunotherapy especially in cancer vaccines, in the current review, we summarize the unique features of SPA that are beneficial for cancer immunotherapy, and highlight important progresses in using SPA as nanoscale carriers, antigens, adjuvants or multifunctional platforms. The current challenges faced by these SPAs are also briefly discussed.

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Publication details

The article was received on 29 Aug 2019, accepted on 08 Oct 2019 and first published on 08 Oct 2019


Article type: Review Article
DOI: 10.1039/C9BM01380F
Biomater. Sci., 2019, Accepted Manuscript

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    Recent progresses in supramolecular peptide assembly as virus mimicry for cancer immunotherapy

    Y. Cai, W. Ran, Y. Zhai, J. Wang, C. Zheng, Y. Li and P. Zhang, Biomater. Sci., 2019, Accepted Manuscript , DOI: 10.1039/C9BM01380F

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