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A clinical trial with a collagen dermal substitute INSUREGRAF® for wound healing in burn patients

Abstract

Human skin incurs damage in various ways; a few of the recognizable factors are electric burns, chemical burns, scalding burns, surgery, and physical injuries, such as automobile accidents. If skin damage is extensive and severe enough [second degree and total body surface area (TBSA) involvement of > 20%], the skin will lose the ability to regenerate itself. Burn wounds are treated in various ways. For full-thickness skin defects, the mainstay of treatment is an autologous split-thickness skin graft. However, there are some limitations due to scars, poor elasticity, and limitations in the joint movements due to contracture. Recently, the artificial dermis has been widely used to minimize contractures. The use of dermal replacement for the treatment of burns brings new hope in maintaining the characteristics of the normal dermis. Herein, Insuregraf® was used for skin regeneration in patients who had burn injury from flame, electricity, heat, or steam. The mean take-rate values at 7 and 14 days after operation were 94.55 ± 3.02% and 97.40 ± 2.57%, respectively. Further, areas covered by Insuregraf® showed higher mean values of trans-epidermal water loss (24.6 ± 3.9 g/hr/m2), gross elasticity (Ua/Uf = 0.76 ± 0.24), and biological elasticity (Ur/Uf = 0.55 ± 0.1). These values were much better than the control where Insuregraf® was not used (p = 0.030, p = 0.040, and p = 0.013, respectively). Further, the biomechanical scar properties of Insuregraf® and Matriderm were very similar. Hence, we suggest that Insuregraf® can be used in the medical field.

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Publication details

The article was received on 01 Aug 2019, accepted on 01 Nov 2019 and first published on 08 Nov 2019


Article type: Paper
DOI: 10.1039/C9BM01209E
Biomater. Sci., 2019, Accepted Manuscript

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    A clinical trial with a collagen dermal substitute INSUREGRAF® for wound healing in burn patients

    D. Yoon, S. Y. Joo, Y. S. Cho, C. Seo and Y. S. Cho, Biomater. Sci., 2019, Accepted Manuscript , DOI: 10.1039/C9BM01209E

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