Doxorubicin-loaded nanoscale metal-organic framework for tumor targeting combined chemotherapy and chemodynamic therapy
Doxorubicin (DOX) as a traditional chemotherapy drug was restricted in clinical application due to the poor therapeutic activity and severe side effect. Herein, we prepared metal-organic frameworks (MOFs) MIL-100 by microwave-assisted synthesis and DOX was loaded in MIL-100, and then hyaluronic acid (HA) was modified on the surface of MIL-100 (DMH NPs). DMH NPs possessed the following advantages: (1) MIL-100 could serve as a drug carrier with high DOX loading efficiency, and meanwhile, MIL-100 could generate hydroxyl radical (·OH) in the presence of H2O2 for chemodynamic therapy (CDT) via Fenton-like reaction. (2) To improve the dispersibility of MIL-100, HA was modified on the surface of MIL-100, and thus could endow MIL-100 with targeting ability towards tumor tissues. (3) DMH NPs could enhance antitumor efficacy and reduce drug-related toxicity though the combination of chemotherapy and chemodynamic therapy. DMH NPs had enormous potential to be a candidate with reducing the systemic toxicity and improving the treatment effect for breast cancer.