Jump to main content
Jump to site search


Doxorubicin-loaded nanoscale metal–organic framework for tumor-targeting combined chemotherapy and chemodynamic therapy

Author affiliations

Abstract

Doxorubicin (DOX) as a traditional chemotherapy drug is restricted in clinical applications due to its poor therapeutic activity and severe side effects. Herein, we prepared a metal–organic framework (MOF) MIL-100 by a microwave-assisted synthesis and DOX was loaded in MIL-100 and then, hyaluronic acid (HA) was modified on the surface of MIL-100 to give DMH NPs. The DMH NPs possessed the following advantages: (1) MIL-100 could serve as a drug carrier with a high DOX loading efficiency; MIL-100 could also generate a hydroxyl radical (˙OH) in the presence of H2O2 for chemodynamic therapy (CDT) via a Fenton-like reaction. (2) To improve the dispersibility of MIL-100, HA was modified on the surface of MIL-100, which could endow MIL-100 with a targeting ability towards tumor tissues. (3) DMH NPs could enhance antitumor efficacy and reduce drug-related toxicity though the combination of chemotherapy and chemodynamic therapy. DMH NPs have enormous potential as a candidate for reducing the systemic toxicity and improving the treatment effect for breast cancer.

Graphical abstract: Doxorubicin-loaded nanoscale metal–organic framework for tumor-targeting combined chemotherapy and chemodynamic therapy

Back to tab navigation

Supplementary files

Publication details

The article was received on 05 Jul 2019, accepted on 07 Aug 2019 and first published on 13 Aug 2019


Article type: Paper
DOI: 10.1039/C9BM01044K
Biomater. Sci., 2019, Advance Article

  •   Request permissions

    Doxorubicin-loaded nanoscale metal–organic framework for tumor-targeting combined chemotherapy and chemodynamic therapy

    T. Xue, C. Xu, Y. Wang, Y. Wang, H. Tian and Y. Zhang, Biomater. Sci., 2019, Advance Article , DOI: 10.1039/C9BM01044K

Search articles by author

Spotlight

Advertisements