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Doxorubicin-loaded nanoscale metal-organic framework for tumor targeting combined chemotherapy and chemodynamic therapy

Abstract

Doxorubicin (DOX) as a traditional chemotherapy drug was restricted in clinical application due to the poor therapeutic activity and severe side effect. Herein, we prepared metal-organic frameworks (MOFs) MIL-100 by microwave-assisted synthesis and DOX was loaded in MIL-100, and then hyaluronic acid (HA) was modified on the surface of MIL-100 (DMH NPs). DMH NPs possessed the following advantages: (1) MIL-100 could serve as a drug carrier with high DOX loading efficiency, and meanwhile, MIL-100 could generate hydroxyl radical (·OH) in the presence of H2O2 for chemodynamic therapy (CDT) via Fenton-like reaction. (2) To improve the dispersibility of MIL-100, HA was modified on the surface of MIL-100, and thus could endow MIL-100 with targeting ability towards tumor tissues. (3) DMH NPs could enhance antitumor efficacy and reduce drug-related toxicity though the combination of chemotherapy and chemodynamic therapy. DMH NPs had enormous potential to be a candidate with reducing the systemic toxicity and improving the treatment effect for breast cancer.

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Publication details

The article was received on 05 Jul 2019, accepted on 07 Aug 2019 and first published on 13 Aug 2019


Article type: Paper
DOI: 10.1039/C9BM01044K
Biomater. Sci., 2019, Accepted Manuscript

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    Doxorubicin-loaded nanoscale metal-organic framework for tumor targeting combined chemotherapy and chemodynamic therapy

    T. Xue, C. Xu, Y. Wang, Y. Wang, H. Tian and Y. Zhang, Biomater. Sci., 2019, Accepted Manuscript , DOI: 10.1039/C9BM01044K

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