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Manganese neurotoxicity: nano-oxide compensates for ion-damage in mammals

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Abstract

Here, we have compared the behavioral neurotoxicity of a manganese nanoformulation (citrate functionalized Mn3O4 nanoparticles; C-Mn3O4 NPs) with that of the well-known neurotoxicant, ionic Mn, in an animal model. We found that mice administered with C-Mn3O4 NPs showed no signs of a neurobehavioral disorder, but the NPs instead ameliorated Mn-induced neurotoxicity (Parkinson's-like syndrome) through the chelation of excess Mn ions and subsequent reduction of oxidative damage.

Graphical abstract: Manganese neurotoxicity: nano-oxide compensates for ion-damage in mammals

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Publication details

The article was received on 05 Jul 2019, accepted on 18 Sep 2019 and first published on 18 Sep 2019


Article type: Communication
DOI: 10.1039/C9BM01039D
Biomater. Sci., 2019, Advance Article

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    Manganese neurotoxicity: nano-oxide compensates for ion-damage in mammals

    A. Adhikari, M. Das, S. Mondal, S. Darbar, A. K. Das, S. S. Bhattacharya, D. Pal and S. K. Pal, Biomater. Sci., 2019, Advance Article , DOI: 10.1039/C9BM01039D

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