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Issue 9, 2019
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Single nanoparticles as versatile phototheranostics for tri-modal imaging-guided photothermal therapy

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Abstract

Development of versatile phototheranostics is highly desirable for cancer theranostics. Herein, a novel organic conjugated polymer (named DPP-TT) with excellent optical properties was designed and prepared. Based on single-component DPP-TT, single DPP-TT NPs as versatile phototheranostics were developed by a simple nanoprecipitation method. The obtained NPs exhibited good water solubility, excellent biocompatibility, outstanding photostability, strong NIR-I light absorption, and appropriate NIR-II fluorescence emission. Importantly, such NPs presented high photothermal conversion efficiency. From the investigations performed in vitro and in vivo, it was observed that DPP-TT NPs show remarkable performance for cancer theranostics, benefiting from single 808 nm laser-induced tri-modal (NIR-II fluorescence/photoacoustic/thermal) imaging-guided photothermal therapy.

Graphical abstract: Single nanoparticles as versatile phototheranostics for tri-modal imaging-guided photothermal therapy

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Publication details

The article was received on 27 Jun 2019, accepted on 15 Jul 2019 and first published on 16 Jul 2019


Article type: Communication
DOI: 10.1039/C9BM00997C
Biomater. Sci., 2019,7, 3609-3613

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    Single nanoparticles as versatile phototheranostics for tri-modal imaging-guided photothermal therapy

    X. Lu, J. Chen, J. Li, B. Xia, J. Xu, Q. Wang, C. Xie, Q. Fan and W. Huang, Biomater. Sci., 2019, 7, 3609
    DOI: 10.1039/C9BM00997C

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