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Tuning the NIR photoabsorption of CuWO4−x nanodots with oxygen vacancies for CT imaging guided photothermal therapy of tumors

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Abstract

A traditional CuWO4 semiconductor (Eg = 2.25 eV) shows photoabsorption in the visible range with an edge at ∼550 nm, limiting its application in near-infrared (NIR) laser-induced photothermal ablation therapy (PAT). To tune the NIR photoabsorption of CuWO4, we report a trisodium citrate-induced strategy for generating oxygen vacancies. CuWO4 and CuWO4−x nanoparticles are prepared by a facile coprecipitation–solvothermal method in the absence or presence of trisodium citrate (0.2–0.5 g) as the reducing agent. Without trisodium citrate, CuWO4 consists of aggregated particles, and its dispersion has a typical yellow-green color without NIR photoabsorption. With the addition of trisodium citrate from 0.2 to 0.5 g, CuWO4−x samples are composed of monodisperse nanodots with increased sizes from ∼2 to ∼6 nm, and the color of these dispersions becomes darker with increased NIR photoabsorption, that is, from 0.178 to 0.685 at 808 nm. As a result, the aqueous dispersion of CuWO4−x-0.5 nanodots prepared with 0.5 g trisodium citrate exhibits a high photothermal efficiency of 47.6% under 808 nm laser irradiation. Simultaneously, CuWO4−x-0.5 nanodots have high X-ray attenuation as a CT imaging agent due to the presence of a heavy metal element (W). When the CuWO4−x-0.5 dispersion is injected into the tumors of mice, the tumors can be observed by CT and thermal imaging. After 808 nm laser irradiation (1.0 W cm−2, 10 min), cancer cells in vivo can be efficiently ablated by the photothermal effects of CuWO4−x, without obvious toxicity and side effects. Therefore, CuWO4−x can act as a novel all-in-one agent for CT imaging-guided photothermal therapy of tumors.

Graphical abstract: Tuning the NIR photoabsorption of CuWO4−x nanodots with oxygen vacancies for CT imaging guided photothermal therapy of tumors

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Publication details

The article was received on 27 Jun 2019, accepted on 08 Aug 2019 and first published on 16 Aug 2019


Article type: Paper
DOI: 10.1039/C9BM00995G
Biomater. Sci., 2019, Advance Article

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    Tuning the NIR photoabsorption of CuWO4−x nanodots with oxygen vacancies for CT imaging guided photothermal therapy of tumors

    M. Wen, S. Wang, R. Jiang, Y. Wang, Z. Wang, W. Yu, P. Geng, J. Xia, M. Li and Z. Chen, Biomater. Sci., 2019, Advance Article , DOI: 10.1039/C9BM00995G

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