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Selenium-doped hydroxyapatite biopapers with an anti-bone tumor effect by inducing apoptosis

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Abstract

One-dimensional hydroxyapatite (HA) particularly mimics the structure of mineralized collagen fibrils and displays superior mechanical properties such as toughness. Herein, we report Se-doped HA/chitosan (Se-HA/CS) biopapers constructed with self-assembled Se-doped HA nanowires and chitosan. The Se-HA/CS biopapers with high flexibility and manufacturability can not only be further processed into arbitrary shapes by folding or using scissors but also display high performances in in vitro/vivo anti-bone tumor studies. The Se-HA/CS biopapers are more inclined to inhibit the growth of tumor cells (HCS 2/8 and SJSA cells) than that of normal human bone marrow stromal cells (hBMSCs). The potential mechanisms of this meaningful anti-tumor effect were investigated, such as reactive oxygen species accumulation and the activation of apoptosis and the underlying signal pathway involved (including caspase family, Bcl-2 family and JNK/STAT3). The results demonstrate that Se-HA/CS biopapers may inhibit the growth of HCS 2/8 and SJSA cells by synchronously inducing JNK activation and STAT3 inhibition and consequently promote the apoptosis of these cells. Furthermore, the in vivo anti-tumor studies confirm that the Se-HA/CS biopapers obviously suppress the growth of patient-derived xenograft tumor models.

Graphical abstract: Selenium-doped hydroxyapatite biopapers with an anti-bone tumor effect by inducing apoptosis

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Publication details

The article was received on 18 Jun 2019, accepted on 31 Aug 2019 and first published on 04 Sep 2019


Article type: Paper
DOI: 10.1039/C9BM00953A
Biomater. Sci., 2019, Advance Article

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    Selenium-doped hydroxyapatite biopapers with an anti-bone tumor effect by inducing apoptosis

    Z. Zhou, T. Sun, Y. Qin, Y. Zhu, Y. Jiang, Y. Zhang, J. Liu, J. Wu, S. He and F. Chen, Biomater. Sci., 2019, Advance Article , DOI: 10.1039/C9BM00953A

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