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Antibody-guided nanomedicines as novel breakthrough therapeutic, diagnostic and theranostic tools

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Abstract

Recent advances in nanotechnology, such as the development of various types of nanoparticles and hybrid nanomaterials, have revolutionized nanomedicine. The small size, customizable surface, enhanced solubility, and multi-functionality endow the nanoparticles with an ability to interact with complex cellular and biological functions in new ways. Furthermore, these systems can deliver drugs to specific tissues and provide a targeted therapy. For this purpose, different categories of molecules, particularly antibodies, have been used as ligands. Antibody-conjugated nanomaterials can significantly enhance the efficiency of nanomedicines, especially in the field of cancer. This review is focused on three major medical applications of antibody-conjugated nanomaterials, namely, therapeutic, diagnostic and theranostic applications. To provide comprehensive information on the topic and an overview of these hybrid nanomaterials for biomedical applications, a brief summary of nanomaterials and antibodies is given. Moreover, the review has depicted the potential applications of antibody-conjugated nanomaterials in different fields and their capabilities to empower nanomedicine, particularly in relation to the treatment and detection of malignancies.

Graphical abstract: Antibody-guided nanomedicines as novel breakthrough therapeutic, diagnostic and theranostic tools

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Publication details

The article was received on 16 Jun 2019, accepted on 10 Jul 2019 and first published on 10 Jul 2019


Article type: Review Article
DOI: 10.1039/C9BM00931K
Biomater. Sci., 2019, Advance Article

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    Antibody-guided nanomedicines as novel breakthrough therapeutic, diagnostic and theranostic tools

    G. Farahavar, S. S. Abolmaali, N. Gholijani and F. Nejatollahi, Biomater. Sci., 2019, Advance Article , DOI: 10.1039/C9BM00931K

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