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Precision control of the large-scale green synthesis of biodegradable gold nanodandelions as potential radiotheranostics

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Abstract

Herein, we report a new type of biodegradable, high surface-area gold nanodandelions (GNDs). This report possesses important features and some are the first of its kind: (1) the large scale green synthesis of GNDs with high monodispersity and a circa 100% yield with consistent chemistry, manufacturing and controls (CMC); (2) cellular/physiological degradability of GNDs leading to its disassembly into debris, which is indicative of the potential for possible body clearance; (3) precision control of the chemicophysical properties of the GNDs including shape, petal number and size, all can be judiciously fine-tuned by the synthetic parameters; (4) highly efficient radiotheranostics of GNDs encompassing better enhanced computed tomography (CT) contrast and pronounced X-ray induced reactive oxygen species (ROS) generation than conventional spherical gold nanoparticles (AuNP). It is noteworthy that the GNDs demonstrate a unique combinational effect of radiosensitization (production of superoxide anions and hydroxyl radicals) and type II photodynamic interaction (generation of singlet oxygen). Given the above, our reported GNDs are promising in clinical translation as radiotheranostics.

Graphical abstract: Precision control of the large-scale green synthesis of biodegradable gold nanodandelions as potential radiotheranostics

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Publication details

The article was received on 10 Jun 2019, accepted on 25 Aug 2019 and first published on 28 Aug 2019


Article type: Paper
DOI: 10.1039/C9BM00897G
Biomater. Sci., 2019, Advance Article

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    Precision control of the large-scale green synthesis of biodegradable gold nanodandelions as potential radiotheranostics

    Y. Chuang, Y. Hsia, C. Chu, L. Lin, M. Sivasubramanian and L. Lo, Biomater. Sci., 2019, Advance Article , DOI: 10.1039/C9BM00897G

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