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Calcium phosphate nanocarriers for drug delivery to tumors: imaging, therapy and theranostics

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Abstract

Calcium phosphate (CaP) was engineered as a drug delivery nanocarrier nearly 50 years ago due to its biocompatibility and biodegradability. In recent years, several approaches have been developed for the preparation of size-controllable, stable and multifunctional CaP nanocarriers, and several targeting moieties have also been decorated on the surface of these nanocarriers for active targeting. The CaP nanocarriers have been utilized for loading probes, nucleic acids, anticancer drugs and photosensitizers for cancer imaging, therapy and theranostics. Herein, we reviewed the recent advances in the preparation strategies of CaP nanocarriers and the applications of these nanocarriers in tumor diagnosis, gene delivery, drug delivery and theranostics and finally provided perspectives.

Graphical abstract: Calcium phosphate nanocarriers for drug delivery to tumors: imaging, therapy and theranostics

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Publication details

The article was received on 29 May 2019, accepted on 31 Jul 2019 and first published on 31 Jul 2019


Article type: Review Article
DOI: 10.1039/C9BM00831D
Biomater. Sci., 2019, Advance Article

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    Calcium phosphate nanocarriers for drug delivery to tumors: imaging, therapy and theranostics

    D. Huang, B. He and P. Mi, Biomater. Sci., 2019, Advance Article , DOI: 10.1039/C9BM00831D

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