Jump to main content
Jump to site search

Issue 9, 2019
Previous Article Next Article

Use of multifunctional composite nanofibers for photothermalchemotherapy to treat cervical cancer in mice

Author affiliations

Abstract

A locally administered combination of chemotherapy and photothermal therapy may be suitable for the treatment of cervical cancer. In this study, doxorubicin (DOX) and indocyanine green (ICG) co-loaded mesoporous silica nanoparticles (DIMSN) were prepared. Then the nanoparticles were incorporated into chitosan/poly(vinyl alcohol) (CS/PVA) to form multifunctional composite nanofibers (DIMSN/F) via the electrospinning process. Under the mimic erosion of vaginal secretion, DIMSN/F presented site-specific drug release while the local delivery of a thermosensitive DIMSN-loaded gel (DIMSN/gel) failed in doing so. The vaginal implantation of DIMSN/F could achieve maximized drug accumulation in the vagina of mice compared to the systematic injection of DIMSN. Finally, the photothermalchemotherapy (PTCT) effects of DIMSN/F were studied in both subcutaneous and orthotopic cervical cancer models in mice but drug penetration in the hard nodular tumor posed a great challenge. For all this, the tumor inhibition rate (TIR) for orthotopic cervical/vaginal cancer was still as high as 72.5%, presenting its great potential for the treatment of cervical cancer.

Graphical abstract: Use of multifunctional composite nanofibers for photothermalchemotherapy to treat cervical cancer in mice

Back to tab navigation

Supplementary files

Publication details

The article was received on 15 May 2019, accepted on 21 Jun 2019 and first published on 01 Jul 2019


Article type: Paper
DOI: 10.1039/C9BM00756C
Biomater. Sci., 2019,7, 3846-3854

  •   Request permissions

    Use of multifunctional composite nanofibers for photothermalchemotherapy to treat cervical cancer in mice

    X. Wang, L. Wang, S. Zong, R. Qiu and S. Liu, Biomater. Sci., 2019, 7, 3846
    DOI: 10.1039/C9BM00756C

Search articles by author

Spotlight

Advertisements