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Non-conjugated polyethylenimine copolymer-based unorthodox nanoprobe for bioimaging and related mechanisms exploration

Abstract

Unconventional non-conjugated photoluminescent polymers have attracted increasing attention in bioimaging application, however their nonclassical photoluminescent mechanisms remain largely unclear. Herein, an amphiphilic copolymer polyethyleneimine-poly(D,L-lactide) (PEI-PDLLA) was synthesized and the obtained PEI-PDLLA copolymer exhibited intrinsic visible blue luminescence in the solid and concentrated solution states under 365 nm UV light irradiation. Using a computational assay approach, we investigated the unconventional photoluminescent mechanism of PEI-PDLLA. The results revealed that such photoluminescence should be related to the “clustered heteroatoms chromophores” formed by through-space electronic interactions of N-heteroatom in PEI. The copolymers can function as a fluorescent nanoprobe (PEI-PDLLA NPs) via a facile nanoprecipitation method and the self-assembly mechanism of PEI-PDLLA NPs was also in-depth investigated by molecular dynamics simulation. Intriguingly, the PEI-PDLLA NPs exhibited a remarkable excitation-dependent multi-wavelength emission characteristic, which was promising in acquiring high precision imaging effect. Moreover, in contrast with conventional organic dyes with aggregation-caused quenching (ACQ), the fluorescence intensity of the PEI-PDLLA NPs was enhanced with increasing solution concentration. Furthermore, their applications in bioimaging indicated that PEI-PDLLA NPs could be utilized as a lysosome-specific and tumor-targeted nanoprobe with excellent photostability and good biocompatibility.

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Supplementary files

Publication details

The article was received on 01 Apr 2019, accepted on 09 May 2019 and first published on 15 May 2019


Article type: Paper
DOI: 10.1039/C9BM00516A
Biomater. Sci., 2019, Accepted Manuscript

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    Non-conjugated polyethylenimine copolymer-based unorthodox nanoprobe for bioimaging and related mechanisms exploration

    L. Shao, K. Wan, H. Wang, Y. Cui, C. Zhao, J. Lu, X. Li, L. Chen, X. Cui, X. Wang, X. Deng, X. Shi and Y. Wu, Biomater. Sci., 2019, Accepted Manuscript , DOI: 10.1039/C9BM00516A

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