Stimuli Responsive PEGylated Bismuth Selenide Hollow Nanocapsules for Fluorescence/CT imaging and Light-Driven Multimodal Tumor Therapy
Stimuli-responsive therapeutic nanosystems exhibit enhanced selectivity and higher biosafety for cancer theranostics via recognizing exogenous or endogenous tumor- associated factors. Herein, we developed a multifunctional nanocomplex (Bi2Se3@PEG/DOX/Ce6 nanocapsules, or BPDC NCs in brief) that was constructed by loading chlorin e6 (Ce6) and doxorubicin (DOX) into PEGylated hollow bismuth sulfide nanocapsules. Upon the administration of BPDC NCs, composite laser irradiation can effectively activate the local hyperthermia generation and the yield of cytotoxic reactive oxygen species (ROS). In another aspect, on-demand drug release can be triggered in mild acidic tumor microenvironment or by thermal shock. Moreover, imaging navigation with respect to infrared thermography, computed tomography (CT) and fluorescence imaging and may potentially monitor the biodistribution of BPDC NCs, thanks to the local hyperthermia generation, fluorescence emission of Ce6 and high Z-element of bismuth. Finally, we demonstrated the tumor site-specific photothermal therapy (PTT), photodynamic therapy (PDT) and chemotherapeutic effects for high efficacious tumor suppression with minimized systemic toxicity. Taken together, these findings indeed provide insights of broadening the application of Bi2Se3 nanocapsules for cancer management and precision medicine.