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Construction of cellulose nanofibers/quaternized chitin/organic rectorite composites and their application as wound dressing materials

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Abstract

Traumatic injury is a major cause of mortality, and poor wound healing affects millions of people. Thus, the development of effective wound dressings is essential for speeding up wound healing and decreasing mortality. In this study, a suspension of carboxylated brown algae cellulose nanofibers (BACNFs) with a high aspect ratio was freeze dried to prepare a sponge. The sponge showed high porosity and water absorption capacity; thus, it can absorb wound exudates when used as a wound dressing. In addition, quaternized β-chitin (QC) with antibacterial properties was intercalated into the interlayer space of the organic rectorite (OREC) via electrostatic interactions to obtain composite suspensions (QCRs) with improved antimicrobial activity compared to that of QC alone. Subsequently, the BACNF sponge was soaked in the QCR suspension to absorb QCRs via electrostatic interactions and hydrogen bonding from which cellulose nanofiber/quaternized chitin/organic rectorite composite (BACNF/QCR) sponges were constructed via freeze-drying. The in vivo animal tests demonstrated that the BACNF/QCR sponges rapidly induced hemostasis in a rat tail amputation test, making them superior to the traditional hemostatic materials. Furthermore, BACNFs/QCRs could substantially promote collagen synthesis and neovascularization, thereby accelerating wound healing 3 days earlier than gauze. This multi-functional biomedical material, fabricated using natural substances, shows great potential to be used for wound healing.

Graphical abstract: Construction of cellulose nanofibers/quaternized chitin/organic rectorite composites and their application as wound dressing materials

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Publication details

The article was received on 21 Feb 2019, accepted on 24 Mar 2019 and first published on 27 Mar 2019


Article type: Paper
DOI: 10.1039/C9BM00288J
Citation: Biomater. Sci., 2019, Advance Article

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    Construction of cellulose nanofibers/quaternized chitin/organic rectorite composites and their application as wound dressing materials

    H. Gao, Z. Zhong, H. Xia, Q. Hu, Q. Ye, Y. Wang, L. Chen, Y. Du, X. Shi and L. Zhang, Biomater. Sci., 2019, Advance Article , DOI: 10.1039/C9BM00288J

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