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Host defense peptide mimicking poly-β-peptides with fast, potent and broad spectrum antibacterial activities

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Abstract

Microbial infections have always been serious challenges to human health considering that antibiotics almost inevitably induce microbial resistance. Therefore, it is urgent to develop a new antibacterial agent that is active against drug-resistant bacteria and is less susceptible to microbial resistance. In this work, a series of host defense peptide (HDP) mimicking antibacterial poly-β-peptides were synthesized, characterized and evaluated for their biological activities. The best poly-β-peptide within this study (20 : 80 Bu : DM) displays potent and broad spectrum antibacterial activity against antibiotic-resistant super bugs and low toxicity toward mammalian cells. Moreover, these poly-β-peptides are bactericidal and kill bacteria very fast within 5 min. An antimicrobial resistance test demonstrated that bacteria develop no resistance toward the selected poly-β-peptides even over 1000 generations. Our studies demonstrate that random copolymers of heterochiral poly-β-peptides, without the need for defined secondary structures, can mimic the antimicrobial HDP. These results imply the potential application of these poly-β-peptides as new antimicrobial agents to tackle drug resistant antimicrobial infections.

Graphical abstract: Host defense peptide mimicking poly-β-peptides with fast, potent and broad spectrum antibacterial activities

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Publication details

The article was received on 15 Feb 2019, accepted on 04 Mar 2019 and first published on 18 Mar 2019


Article type: Paper
DOI: 10.1039/C9BM00248K
Citation: Biomater. Sci., 2019, Advance Article

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    Host defense peptide mimicking poly-β-peptides with fast, potent and broad spectrum antibacterial activities

    Q. Zhang, P. Ma, J. Xie, S. Zhang, X. Xiao, Z. Qiao, N. Shao, M. Zhou, W. Zhang, C. Dai, Y. Qian, F. Qi and R. Liu, Biomater. Sci., 2019, Advance Article , DOI: 10.1039/C9BM00248K

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