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Enhancing the Effects of Transcranial Magnetic Stimulation with Intravenously Injected Magnetic Nanoparticles

Abstract

Transcranial magnetic stimulation (TMS) is a noninvasive and clinically approved method for treating neurological disorders. But the relatively weak intracranial electric current induced by TMS is an obvious inferiority, which can only produce limited treatment effects in clinical application. The present study aimed to investigate the possibility of enhancing the effects of TMS with intravenously administrated magnetic nanoparticles. To facilitate the nanoparticles crossing of the blood-brain barrier (BBB), superparamagnetic iron oxide nanoparticles (SPIONs) were coated with carboxylated chitosanand poly (ethylene glycol). To promote nanoparticles crossing BBB and targeting to the predesigned brain regions, an external permanent magnet was attached to the forehead of rats before the intravenous administration of SPIONs. The electrophysiological test showed that the maximum MEP amplitude recorded in an individual rat was significantly higher in SPIONs+magnetnet group than that in saline group (5.78 ± 2.54 vs 1.80 ± 1.55mV, P = 0.015). The biochemical test detected that in the M1 region, the number density of c-fos positive cells in the SPIONs+magnetnet group was 3.44 folds of that in the saline group. These results suggested that intravenouslyinjected SPIONs may boost the effects of TMS in treating neurological disorders.

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Publication details

The article was received on 02 Feb 2019, accepted on 01 Apr 2019 and first published on 10 Apr 2019


Article type: Paper
DOI: 10.1039/C9BM00178F
Citation: Biomater. Sci., 2019, Accepted Manuscript

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    Enhancing the Effects of Transcranial Magnetic Stimulation with Intravenously Injected Magnetic Nanoparticles

    R. Li, J. Wang, X. Yu, P. Xu, S. Zhang, J. Xu, Y. Bai, Z. Dai, Y. Sun, R. Ye, Z. Xia, X. Liu, G. Ruan and G. Xu, Biomater. Sci., 2019, Accepted Manuscript , DOI: 10.1039/C9BM00178F

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