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A facile dopamine-mediated metal-catecholamine coating for therapeutic nitric oxide gas interface-catalytic engineering of vascular devices

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Abstract

Developing a facile and versatile strategy to endow blood-contacting devices with surface in situ nitric oxide (NO) generation properties by catalytically decomposing endogenously existing S-nitrosothiols (RSNO) from blood is of immense scientific and engineering interest. However, most available strategies involve drawbacks of low efficiency, complex processes, and toxic chemicals. In this work, we report a facile method to deposit a NO-generating coating on a 316L stainless steel (SS) substrate through dopamine-mediated one-step assembly of CuII-dopamine (CuII-DA) coordination complexes. The chelation of CuII in the CuII-DA network endowed the coating with high in situ NO catalytic capacity by decomposing RSNO endogenously existing in blood. Of special importance is that this dopamine-mediated method possesses the merits of a simple preparation process, friendliness to the environment, high controllability of the CuII-DA surface chemistry, highly effective surface coating formation, and long-term and durable catalytic activity of NO. The continuous release of NO from the CuII-DA-coated 316L SS impressively improved its antithrombogenicity and selectively enhanced endothelial cell (EC) growth while inhibiting smooth muscle cell (SMC) proliferation.

Graphical abstract: A facile dopamine-mediated metal-catecholamine coating for therapeutic nitric oxide gas interface-catalytic engineering of vascular devices

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Publication details

The article was received on 04 Jan 2019, accepted on 23 Jun 2019 and first published on 01 Jul 2019


Article type: Paper
DOI: 10.1039/C9BM00017H
Biomater. Sci., 2019, Advance Article

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    A facile dopamine-mediated metal-catecholamine coating for therapeutic nitric oxide gas interface-catalytic engineering of vascular devices

    Q. Song, L. Li, K. Xiong, W. Tian, J. Lu, J. Wang, N. Huang, Q. Tu and Z. Yang, Biomater. Sci., 2019, Advance Article , DOI: 10.1039/C9BM00017H

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