Jump to main content
Jump to site search


Development of a microdevice-based human mesenchymal stem cell-mediated drug delivery system

Author affiliations

Abstract

Cell-mediated drug delivery systems utilize living cells as vehicles to achieve controlled delivery of drugs. One of the systems features integrating cells with disk-shaped microparticles termed microdevices into cell-microdevice complexes that possess some unique advantages over their counterparts. Human mesenchymal stem cells (hMSCs) have been extensively studied as therapeutic cells and used as carrier cells for drug-loaded nanoparticles or other functional nanoparticles. This article presents the development of a microdevice-based hMSC-mediated drug delivery system for the first time. This study revealed that the microdevices could be attached to the hMSCs in a controlled and versatile manner; the produced hMSC-microdevice complexes were stable over cultivation and trypsinization, and the microdevice attachment did not affect the viability and proliferation of the hMSCs. Moreover, cultured microdevice-bound hMSCs retained their abilities to migrate on a flat surface, form a spheroid, and actively dissociate from the spheroid. These results indicate that this microdevice-based hMSC-mediated system promises to be further developed into a clinically viable drug delivery system.

Graphical abstract: Development of a microdevice-based human mesenchymal stem cell-mediated drug delivery system

Back to tab navigation

Publication details

The article was received on 16 Dec 2018, accepted on 09 Mar 2019 and first published on 11 Mar 2019


Article type: Paper
DOI: 10.1039/C8BM01634H
Biomater. Sci., 2019, Advance Article

  •   Request permissions

    Development of a microdevice-based human mesenchymal stem cell-mediated drug delivery system

    J. Xia, A. Tsai, W. Cheng, X. Yuan, T. Ma and J. Guan, Biomater. Sci., 2019, Advance Article , DOI: 10.1039/C8BM01634H

Search articles by author

Spotlight

Advertisements