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Synthesis and function of amphiphilic glucan dendrimers as nanocarriers for protein delivery

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Abstract

We report the combined enzymatic synthesis of five glucan dendrimers with control of molecular weight and particle size. Amphiphilic properties were introduced through dodecyl group substitution. A Tokyo-green fluorescence assay showed that amphiphilic glucan dendrimers were able to successfully deliver active β-galactosidase to cells.

Graphical abstract: Synthesis and function of amphiphilic glucan dendrimers as nanocarriers for protein delivery

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Publication details

The article was received on 14 Dec 2018, accepted on 15 Jan 2019 and first published on 30 Jan 2019


Article type: Paper
DOI: 10.1039/C8BM01627E
Citation: Biomater. Sci., 2019, Advance Article

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    Synthesis and function of amphiphilic glucan dendrimers as nanocarriers for protein delivery

    S. Takeda, T. Nishimura, K. Umezaki, A. Kubo, M. Yanase, S. Sawada, Y. Sasaki and K. Akiyoshi, Biomater. Sci., 2019, Advance Article , DOI: 10.1039/C8BM01627E

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