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Bioadhesive anisotropic nanogrooved microfibers directing three-dimensional neurite extension

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Abstract

Neurodegenerative diseases and acute nerve injuries are becoming global clinical problems. Engineering three-dimensional (3D), anisotropic neural cellular structures in vitro is therefore desirable in the regenerative medicine research community. Here, we present, for the first time, a single-step, facile but delicate, fabrication of a 3D macroporous microfibrous scaffold with both anisotropic nanogrooved topography and in situ functionalization with a mussel inspired bioadhesive, poly(norepinephrine) (pNE). Specifically, immiscible blends of polycaprolactone (PCL) and polyethylene oxide (PEO) were electrospun into a grounded coagulation bath containing the precursor of pNE. Upon jet entrance in the bath, both phase-separation-driven longitudinal nanotopography and in situ pNE surface functionalization were introduced on individual microfibers that were packed into a 3D macroporous structure. The resulting scaffold significantly promoted 3D neurite extension capacity, 8-fold higher neurite extension over the isotropic counterpart, demonstrating that such a scaffold has great promise in 3D neural cell culture for nerve tissue modelling and engineering.

Graphical abstract: Bioadhesive anisotropic nanogrooved microfibers directing three-dimensional neurite extension

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Publication details

The article was received on 10 Dec 2018, accepted on 11 Mar 2019 and first published on 11 Mar 2019


Article type: Paper
DOI: 10.1039/C8BM01603H
Citation: Biomater. Sci., 2019, Advance Article

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    Bioadhesive anisotropic nanogrooved microfibers directing three-dimensional neurite extension

    Y. Chen, M. B. Taskin, Z. Zhang, Y. Su, X. Han and M. Chen, Biomater. Sci., 2019, Advance Article , DOI: 10.1039/C8BM01603H

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