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Disparate effects of PEG or albumin based surface modification on uptake of nano- and micro-particles

Abstract

Surface modification of particulate systems is a commonly employed strategy to alter their interaction with proteins and cells. Past studies on nano-particles have shown that surface functionalization with polyethylene glycol (PEG) or proteins such as albumin increases circulation times by reducing their phagocytic uptake. However, studies on surface functionalized micro-particles have reported contradictory results. Here, we investigate the effects of surface functionalization using polystyrene particles with 4 different diameters ranging from 30 nm-2.6 µm and coating them either with albumin or PEG. Our results show that with increasing particle size, surface functionalization has less to no effect on altering phagocytic uptake. The data also suggests that these differences are observed even with a dense arrangement of molecules on the surface (dense brush conformation for PEG conjugation), appear to be independent of the serum proteins adsorbing on particles surfaces and is independent of the endocytic uptake pathway. These results provide insight into the differences in the ability of surface modified nano- and micro-particles to avoid phagocytic uptake.

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Publication details

The article was received on 30 Nov 2018, accepted on 09 Jan 2019 and first published on 09 Jan 2019


Article type: Paper
DOI: 10.1039/C8BM01545G
Citation: Biomater. Sci., 2019, Accepted Manuscript
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    Disparate effects of PEG or albumin based surface modification on uptake of nano- and micro-particles

    P. Sharma, D. Sen, V. Neelakantan, V. Shankar and S. Jhunjhunwala, Biomater. Sci., 2019, Accepted Manuscript , DOI: 10.1039/C8BM01545G

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