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Platelet-derived nanovesicles for hemostasis without release of pro-inflammatory cytokines

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Abstract

Natural platelet-derived nanovesicles with a vacant core were prepared by hypotonic sonication. The nanovesicles efficiently formed platelet-like aggregates using membrane protein in the presence of thrombin and calcium chloride without a notable release of pro-inflammatory cytokines. These natural and biocompatible platelet-derived nanovesicles have great potential as biomaterials for inflammation-free injectable hemostasis.

Graphical abstract: Platelet-derived nanovesicles for hemostasis without release of pro-inflammatory cytokines

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Publication details

The article was received on 15 Nov 2018, accepted on 24 Dec 2018 and first published on 09 Jan 2019


Article type: Communication
DOI: 10.1039/C8BM01480A
Citation: Biomater. Sci., 2019, Advance Article

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    Platelet-derived nanovesicles for hemostasis without release of pro-inflammatory cytokines

    H. Jung, Y. Y. Kang and H. Mok, Biomater. Sci., 2019, Advance Article , DOI: 10.1039/C8BM01480A

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