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Control of stem cell response and bone growth on biomaterials by fully non-peptidic integrin selective ligands

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Abstract

In this communication we report that anchoring αvβ3 or α5β1 integrin-selective RGD peptidomimetics to titanium efficiently tunes mesenchymal stem cell response in vitro and bone growth in rat calvarial defects. Our results demonstrate that this molecular chemistry-derived approach could be successful to engineer instructive coatings for orthopedic applications.

Graphical abstract: Control of stem cell response and bone growth on biomaterials by fully non-peptidic integrin selective ligands

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Publication details

The article was received on 13 Nov 2018, accepted on 25 Jan 2019 and first published on 05 Feb 2019


Article type: Communication
DOI: 10.1039/C8BM01466C
Citation: Biomater. Sci., 2019, Advance Article

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    Control of stem cell response and bone growth on biomaterials by fully non-peptidic integrin selective ligands

    R. Fraioli, S. Neubauer, F. Rechenmacher, B. M. Bosch, K. Dashnyam, J.-H. Kim, R. A. Perez, H.-W. Kim, F. J. Gil, M. P. Ginebra, J. M. Manero, H. Kessler and C. Mas-Moruno, Biomater. Sci., 2019, Advance Article , DOI: 10.1039/C8BM01466C

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